Bioactive Small Molecules
Cayman Chemical ANTIBODY ZIbotentn 1mg
A selective ETA receptor antagonist (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively); inhibits ET-1-induced growth of HEY, OVCA 433, SKOV3, and A2780 cells in vitro; reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2 in HEY cells; reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner (10-50 mg/kg per day)
Medchemexpress LLC Ethoxyacetic acid | 627-03-2 | MFCD00004310 | 98.0% | 104.11 g/mol | C4H8O3 | 10 G
Ethoxyacetic acid is an endogenous metabolite supplied as a high-purity analytical standard for research use. It is provided as a colorless to light-yellow liquid (C4H8O3) with characterized molecular weight and documented quality data, intended for biochemical, analytical, and formulation studies.
- Purity 98.0% (NMR) for analytical reliability.
- Molecular weight 104.11 g/mol; formula C4H8O3 for accurate calculations.
- High solubility in DMSO (75 mg/mL) for easy preparation of stock solutions.
- Available in multiple liquid package sizes suitable for lab-scale use.
- Batch-specific certificate of analysis and SDS available for quality control.
TARGETMOL CHEMICALS INC ALVIMOPAN 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Alvimopan (LY 246736) is a synthetic trans-3 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration this agent binds to mu-opioid receptors in the gut thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone. purity: 99%
Abcam MRS 1754, A2B antagonist, 50MG
MW 486.5 Da, Purity >98%. Selective A2B antagonist (Ki values are 1.97 (hA2B), 403 (hA1), 503 (hA2A), and 570 nM (hA3)).
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC FGFR-3 Human HEK29 2ug
Recombinant human FGFR-3 alpha (IIIc) extracellular domain fused to a human Fc, expressed in HEK293 cells and supplied as a lyophilized powder for research use. The protein is validated for bioactivity and quality, with low endotoxin and high purity to support biochemical and cell-based assays.
- Human extracellular FGFR-3 domain fused to human Fc for improved stability and detection.
- Expressed in HEK293 cells to provide mammalian post-translational modifications.
- Lyophilized formulation for long-term storage and transport.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Endotoxin below 1 EU/μg as measured by LAL.
- Bioactivity validated in cell-based proliferation assays with low ng/mL ED50.
- Reconstitute at ≥100 μg/mL; add carrier protein for long-term storage.
- Store frozen; stable at -20°C for long-term, and 4°C short-term after reconstitution.
Cayman Chemical ANTIBODY OdnacatIb 10mg
A potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively)
Cayman Chemical ANTIBODY AMG 517 50mg
A TRPV1 antagonist (IC50 = 0.9 nM); inhibits mechanical and thermal allodynia in a rat model of burn injury at 165 UG, intrathecally; reverses increases in the level of CGRP and increases expression of GFAP and GAP-43 in the dorsal horn of the spinal cord, as well as enhances axonal regeneration in a rat model of sciatic nerve transection injury
Selleck Chemical LLC Isuzinaxib S0777-25MG
Isuzinaxib (APX-115 free base Ewha-18278 free base) is a potent orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1 08 M 0 57 M and 0 63 M for Nox1 Nox2 and Nox4 respectively APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2 IL-6 and TNF in the diabetic kidney
Medchemexpress LLC HY-100432 25mg Medchemexpress, LOC14 CAS:877963-94-5 Purity:>98%
Medchemexpress, HY-100432 25mg LOC14 CAS:877963-94-5 LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical PB22 6hydroxyquInolIn Isom 5mg
A structural isomer of PB-22; intended for forensic and research purposes
Cayman Chemical ANTIBODY DMNQ 25mg
A 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation
Medchemexpress LLC PqsR/LasR-IN-3 | 2581109-51-3 | 311.35 | 50 MG
PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in *P. aeruginosa*. This compound acts as an antibiotic, targeting bacterial pathways for anti-infection purposes.
- Potent inhibitor of PqsR and LasR systems in *P. aeruginosa*
- Inhibits hERG with an IC₅₀ of 109.01 μM
- Acts as an antibiotic
- Targets bacterial pathways for anti-infection
Selleck Chemical LLC Danicopan S0803-10MM/1ML
Danicopan is a potent selective and orally active inhibitor of factor D with Kd of 0 54 nM for human Factor D Danicopan inhibits alternative pathway of complement (APC) activity and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)
Cayman Chemical ANTIBODY ML-239 25mg
An inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM); alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways
Cayman Chemical ANTIBODY CAY10581 5mg
A naphthoquinone derivative that potently and reversibly inhibits indoleamine 2,3-dioxygenase (IC50 = 55 nM); a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT)